Valsalva menon biography
- Our objective was to evaluate differences in neural responses across the gyri of the left and right insular cortices to autonomic stimuli, the Valsalva maneuver.
- A number of mechanical triggers have been linked to SCAD events, including extreme Valsalva-type manoeuvres and the provocation of coronary.
- A lethal, genetic disorder characterized by severe deformation of elastic arteries, was linked to novel mutations in the FBLN4 gene.
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Abstract
The benefits of exercise for cardiovascular and general health are many. However, sudden cardiac death (SCD) may occur in apparently healthy athletes who perform at the highest levels. A diverse spectrum of diseases is implicated in SCD in athletes, and while atherosclerotic coronary artery disease predominates in individuals of >35 years of age, primary cardiomyopathies and ion channelopathies are prevalent in young individuals. Prevention of SCD in athletes relies on the implementation of health policies aimed at the early identification of arrhythmogenic diseases (such as cardiac screening) and successful resuscitation (such as widespread utilization of automatic external defibrillators and training members of the public on cardiopulmonary resuscitation). This review will focus on the epidemiology and aetiologies of SCD in athletes, and examine fallacies in the approach to this controversial field. Furthermore, potential strategies to prevent these tragic events will be discussed, analysing current practice, gaps in knowledge and future directions.
Keywords: car
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Professor John O'Brien
Blood inflammation relates to neuroinflammation and survival in frontotemporal lobar degeneration
DOI:http://doi.org/10.1093/brain/awae269Journal: Brain
E-pub date: 3 Feb 2025
Authors:
Peripheral innate immunophenotype in neurodegenerative disease: blood-based profiles and links to survival.
DOI:http://doi.org/10.1038/s41380-024-02809-wJournal: Mol Psychiatry
E-pub date: 29 Oct 2024
Authors: A Strauss, P Swann, SL Kigar, R Christou, N Savinykh Yarkoni, L Turner, AG Murley, L Chouliaras, N Shapiro, NJ Ashton, G Savulich, WR Bevan-Jones, A Surendranthan, K Blennow, H Zetterberg, JT O'Brien, JB Rowe, M Malpetti
The PREVENT dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia
DOI:http://doi.org/10.1093/braincomms/fcae189Journal: Brain Commun
E-pub date: 1 Aug 2024
Authors:
APOE e4 exacerbates age-dependent deficits in cortical microstructure
DOI:http://doi.org/10.1093/braincomms/fcad351Journal: Brain Commun
E-pub
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Abstract
Background
Vascular elasticity is crucial for maintaining hemodynamics. Molecular mechanisms involved in human elastogenesis are incompletely understood. We describe a syndrome of lethal arteriopathy associated with a novel, identical mutation in the fibulin 4 gene (FBLN4) in a unique cohort of infants from South India.
Methods
Clinical characteristics, cardiovascular findings, outcomes and molecular genetics of twenty-two infants from a distinct population subgroup, presenting with characteristic arterial dilatation and tortuosity during the period August 2004 to June 2011 were studied.
Results
Patients (11 males, 11 females) presented at median age of 1.5 months, belonging to unrelated families from identical ethno-geographical background; eight had a history of consanguinity. Cardiovascular features included aneurysmal dilatation, elongation, tortuosity and narrowing of the aorta, pulmonary artery and their branches. The phenotype included a variable combination of cutis laxa (52%), long philtrum-thin vermillion (90%), micrognathia (43%), hypertelorism (57%), p
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